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Molecular Targeted Radiosensitizers Opportunities and Challenges [electronic resource]
Willers, Henning
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| 자료유형 | 단행본 |
|---|---|
| 개인저자 | Willers, Henning.,editor. Eke, Iris.,editor. |
| 단체저자명 | SpringerLink (Online service). |
| 서명/저자사항 | Molecular Targeted Radiosensitizers [electronic resource] : Opportunities and Challenges / edited by Henning Willers, Iris Eke. |
| 판사항 | 1st ed. 2020. |
| 형태사항 | XI, 364 p. 42 illus., 38 illus. in color:online resource. |
| 총서사항 | Cancer Drug Discovery and Development=2196-9914 |
| 총서부출표목 | Cancer Drug Discovery and Development, |
| 기본자료 저록 | Springer Nature eBook |
| 기타형태 저록 | Printed edition:9783030497002Printed edition:9783030497026Printed edition:9783030497033 |
| ISBN | 9783030497019 |
| 기타표준부호 | 10.1007/978-3-030-49701-9 |
| 내용주기 | Introduction to Molecular Targeted Radiosensitizers: Opportunities and Challenges -- Translating Targeted Radiosensitizers into the Clinic -- Cartography of the Radiogenome of Human Cancers -- Mechanisms and Markers of Clinical Radioresistance -- Preclinical Strategies for Testing of Targeted Radiosensitizers -- 3D Radiation Biology for Identifying Radiosensitizers -- Preclinical in vivo evaluation of novel radiosensitizers by local tumor control experiments -- Genetically Engineered Mouse Models for Studying Radiation Biology and Radiosensitizers -- Targeting the DNA Damage Response for Radiosensitization -- Targeting Tumor Metabolism to Overcome Radioresistance.-Targeting Tumor Hypoxia -- Normalizing the Tumor Microenvironment for Radiosensitization -- Radiosensitizers in the Era of Immuno-Oncology -- Index. |
| 요약 | Molecular Targeted Radiosensitizers: Opportunities and Challenges provides the reader with a comprehensive review of key pre-clinical research components required to identify effective radiosensitizing drugs. The book features discussions on the mechanisms and markers of clinical radioresistance, pre-clinical screening of targeted radiosensitizers, 3D radiation biology for studying radiosensitizers, in vivo determinations of local tumor control, genetically engineered mouse models for studying radiosensitizers, targeting the DNA damage response for radiosensitization, targeting tumor metabolism to overcome radioresistance, radiosensitizers in the era of immuno-oncology, and more. Additionally, the book features discussions on high-throughput drug screening, predictive biomarkers, pre-clinical tumor models, and the influence of the tumor microenvironment and the immune system, with a specific focus on the challenges radiation oncologists and medical oncologists currently face in testing radiosensitizers in human cancers. Edited by two acclaimed experts in radiation biology and radiosensitizers, with thirteen chapters contributed by experts, this new volume presents an in-depth look at current developments within a rapidly moving field, with a look at where the field will be heading and providing comprehensive insight into the framework of targeted radiosensitzer development. Essential reading for investigators in cancer research and radiation biology. |
| 일반주제명 | Cancer. Radiology. Pharmacology. Cancer Biology. Radiology. Pharmacology. |
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