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Neuroendocrine Neoplasia Management New Approaches for Diagnosis and Treatment [electronic resource]
Beretta, Giordano
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| 자료유형 | 단행본 |
|---|---|
| 개인저자 | Beretta, Giordano.,editor. Berruti, Alfredo.,editor. Bombardieri, Emilio.,editor. Fazio, Nicola.,editor. Goletti, Orlando.,editor. |
| 단체저자명 | SpringerLink (Online service). |
| 서명/저자사항 | Neuroendocrine Neoplasia Management [electronic resource] : New Approaches for Diagnosis and Treatment / edited by Giordano Beretta, Alfredo Berruti, Emilio Bombardieri, Nicola Fazio, Orlando Goletti. |
| 판사항 | 1st ed. 2021. |
| 형태사항 | XIV, 331 p. 52 illus., 48 illus. in color:online resource. |
| 기본자료 저록 | Springer Nature eBook |
| 기타형태 저록 | Printed edition:9783030728298Printed edition:9783030728311Printed edition:9783030728328 |
| ISBN | 9783030728304 |
| 기타표준부호 | 10.1007/978-3-030-72830-4 |
| 내용주기 | Part-1: General. History of Neuroendocrine Neoplasia -- Epidemiology of neuroendocrine neoplasms. Part-2: Diagnosis. New concepts in patholog -- Molecular Biology of Neuroendocrine Tumors -- Circulating biochemical markers of gastro-entero-pancreatic (GEP) neuroendocrine neoplasms (NENs) -- Advances in diagnostic imaging. Part-3: New Approaches for Treatment. Treatment of NET related symptoms -- New Surgical Strategies -- New approaches in medical therapies -- Loco-regional Therapies of NEN -- Radioreceptor therapy -- NETs of the lung -- Part-4: Treatment of NETs From Different Organ Origin. Gastric Neuroendocrine Tumors -- Treatment of Pancreatic Neurendocrine Tumors -- Treatment of intestinal NETs (including appendix) -- Treatment of NETs from rare origin -- Neuroendocrine Neoplasms with Peculiar Biology and Features: MEN1, MEN2A, MEN2B, MEN4, VHL, NF1. Part-5: NETs with Peculiar Biology and Feature. Mixed Neuroendocrine and Non-Neuroendocrine Neoplasms ( Mi NEN) -- Merkel Cell Carcinoma -- Therapy in poorly differentiated neuroendocrine neoplasms (NEN G3) -- Conclusion:NENs management today looking at the future. |
| 요약 | This book provides the most recent update on the management of neuroendocrine neoplasia (NEN), a term covering all tumors of various organs and/or with a particular histology, including MEN (multiple endocrine neoplasia) related tumors, MiNEN (mixed neuroendocrine-non-neuroendocrine neoplasms), NEC (neuroendocrine carcinoma) and Merkel’s carcinoma. NENs are heterogeneous in their biology, clinical presentation and prognosis, showing a great variability in aggressiveness and therapy response. As a result, their treatment is based on a large spectrum of options. The standard therapies are surgery in early disease, various loco-regional procedures in certain conditions and mostly of a palliative nature in metastatic disease. At present, thanks to our increased understanding of molecular signaling pathways, several pharmacological approaches can be used in patients with advanced NENs. Somatostatin analogs display both anti-tumor effects and symptom control. Novel peptide-radio-receptor treatment (PRRT) is used in patients with well differentiated tumors. The agents targeting angiogenesis and/or PI3K/AKT/mTOR pathway, alone or in combination with analogues, have provided encouraging results in advanced disease. The first part of the book focuses on the history, epidemiology and the most relevant scientific achievements, covering the discoveries in genetic and molecular biology, the endoscopic techniques with guided biopsy, and the metabolic imaging with hybrid PET/CT and MRI/CT. It particularly highlights the emerging strategies in therapy, surgery and mini-invasive surgery as well as loco-regional and systemic treatments, including targeted therapy and/or biological therapies. The second part then explores the management of NENs of various anatomical origins and/or with peculiar biology. It describes the range of the current options and the most relevant results from the clinical trials. This informative book provides valuable insights for all those interested in the management of neuroendocrine neoplasia. |
| 일반주제명 | Oncology. Nuclear medicine. Endocrinology. Surgery. Oncology. Nuclear Medicine. Endocrinology. Surgery. |
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